Experimental Studies on the Response of Nude Mouse-Grown Human Urothelial Cancer to High Dose of 1-β-D-Arabinofuranosylcytosine
作者:
KyriazisAndreas P.,
YagodaAlan,
KyriazisAikaterini A.,
RoyerGeorge L.,
期刊:
Cancer Investigation
(Taylor Available online 1988)
卷期:
Volume 6,
issue 2
页码: 145-149
ISSN:0735-7907
年代: 1988
DOI:10.3109/07357908809077042
出版商: Taylor&Francis
数据来源: Taylor
摘要:
AbstractThe effect of 1-β-D-arabinofuranosylcytosine (ara-C) on human bladder transitional cell carcinomas (TCC) was evaluated using nude mouse-grown established tumor lines SW-780, SW-1738, TCC-K1, and PR49. In the nude mouse tumors grew subcutaneously and evaluation of response to treatment was based on tumor volume analysis. Ara-C was administered intraperitoneally at a dosage of 250 mg/kg on days 1 to 4. All four tumor lines showed an initial phase of considerable regression during the treatment week. This was followed by a variable period of tumor growth arrest after which a gradual tumor regrowth was observed. The results of the present study suggested that ara-C may alter the growth rate of TCC, its effect becoming apparent during the time of its administration and for a short period thereafter. These observations indicate that more studies are warranted at both the experimental and clinical levels to further evaluate dosage and treatment schedule. The results of such additional studies may determine the importance of ara-C in the management of patients with bladder cancer.
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