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Schizophrenia and GABAAreceptor subunit genes

 

作者: W. Byerley,   M. Bailey,   A. Hicks,   B. Riley,   M. Darlison,   J. Holik,   M. Hoff,   F. Umar,   F. Reimherr,   P. Wender,   M. Myles-Worsley,   M. Waldo,   R. Freedman,   K. Johnson,   H. Coon,  

 

期刊: Psychiatric Genetics  （OVID Available online 1995）
卷期: Volume 5, issue 1  

页码: 23-30

 

ISSN:0955-8829

 

年代: 1995

 

出版商: OVID

 

关键词: Schizophrenia;GABAA;Receptor Subunit Genes;Linkage analysis

 

数据来源: OVID

 

摘要:

Alterations in γ-aminobutyric acid (GABA) neurotransmission have been indirectly implicated in the pathogenesis of schizophrenia. Using nine multiplex pedigrees, we tested for linkage between schizophrenia and simple sequence repeat polymorphisms for the GABAAreceptor α1, α2, α4, α5, α6, β1 and β3 subunit genes. Evidence of linkage was not found when assuming either autosomal dominant or autosomal recessive inheritance. The non-parametric sib pair test also did not reveal significant evidence of deviation from expected segregation ratios.

 

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