Barrier Impairment and Immune Reaction in the Cerebrospinal Fluid
作者:
H. Glasner,
期刊:
European Neurology
(Karger Available online 1975)
卷期:
Volume 13,
issue 4
页码: 304-314
ISSN:0014-3022
年代: 1975
DOI:10.1159/000114685
出版商: S. Karger AG
关键词: Cerebrospinal fluid;Protein electrophoresis;Immunoglobulins;Blood-CSF barrier;Immune reaction
数据来源: Karger
摘要:
Investigations on pathophysiological processes in the CSF space due to impairment of the blood-CSF barrier and due to an immune reaction are reported. Barrier disturbances and immune reaction are demonstrated by means of absolute values of CSF protein electrophoresis and by measurement of immunoglobulins. With inflammatory diseases of the CNS, an altered blood-CSF barrier will often be seen at the moment of the first lumbar puncture. Multiple sclerosis, subacute leucoencephalitis and neurosyphilis show signs of a distinct immune reaction together with an increase of the γ-globulins as well as the immunoglobulin G in the absence or slight presence of a barrier impairment. Non-inflammatory diseases of the CNS have variable barrier disturbances
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