Growth Hormone Secretion in Prader‐Willi Syndrome
作者:
H. COSTEFF,
V. A. HOLM,
R. RUVALCABA,
J. SHAVER,
期刊:
Acta Pædiatrica
(WILEY Available online 1990)
卷期:
Volume 79,
issue 11
页码: 1059-1062
ISSN:0803-5253
年代: 1990
DOI:10.1111/j.1651-2227.1990.tb11383.x
出版商: Blackwell Publishing Ltd
关键词: Prader‐Willi syndrome;hypostature;growth hormone 12‐hour integrated study;thyroid function
数据来源: WILEY
摘要:
ABSTRACT.Integrated 12‐hour growth hormone secretion studies, peak growth hormone response to clonidine provocation. Somatomedin‐C levels, T‐4 and TSH levels were studied in six growth‐retarded children with the Prader‐Willi syndrome, of whom five had a 15 q‐karyotype. Only one of the subjects was obese. All showed abnormally low growth hormone secretion. None achieved a nocturnal peak above 10 μg/l, none had a mean nocturnal level over 1.8, and none showed a level above 8 μg/l after clonidine provocation. These findings contrasted with normal TSH in all and normal T‐4 in five. These findings suggest that the poor linear growth in the Prader‐Willi syndrome is caused by a true deficiency of growth hormone secretion, and that the low growth hormone levels observed in such cases are not an a
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