Comparison ofin vivoandin vitroCapability of Complement Fixation by Pemphigus Antibodies
作者:
Takeji Nishikawa,
Seiichi Kurihara,
Hitoshi Hatano,
期刊:
Dermatology
(Karger Available online 1979)
卷期:
Volume 159,
issue 4
页码: 290-294
ISSN:1018-8665
年代: 1979
DOI:10.1159/000250617
出版商: S. Karger AG
关键词: Pemphigus;Complement immunofluorescence;Pemphigus antibodies
数据来源: Karger
摘要:
Using complement immunofluorescence, the capability of complement fixation by bound antibodies in pemphigus lesional skin was compared with circulating intercellular antibodies of complement-fixing type in the same patient. Five lesional skin samples from 6 patients, containing bound IgG, gave positive binding of complement (C3) supplied from fresh guinea pig serum, while only one serum sample showed complement-fixing pemphigus antibodies in the circulation. These results support the view that complement-fixing pemphigus antibodies are rapidly localized to the skin and play a role on the production of acantholysis.
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