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Evaluation of the teratogenic effects of hydrazine, methylhydrazine, and dimethylhydraz...
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Evaluation of the teratogenic effects of hydrazine, methylhydrazine, and dimethylhydrazine on embryos ofXenopus laevis, the South African Clawed Toad
作者:
Gerald Greenhouse,
期刊:
Teratology
(WILEY Available online 1976)
卷期:
Volume 13,
issue 2
页码: 167-177
ISSN:0040-3709
年代: 1976
DOI:10.1002/tera.1420130207
出版商: Wiley Subscription Services, Inc., A Wiley Company
数据来源: WILEY
摘要:
AbstractXenopus laevis embryos were exposed to hydrazine and its methylated derivatives, (mono)methylhydrazine, 1,2‐dimethylhydrazine (SDMH), and 1,1‐dimethylhydrazine (UDMH). Concentrations of hydrazine, methylhydrazine, and UDMH in excess of 10 mg/1 were teratogenic; SDMH was teratogenic at concentrations of 50 mg/1 or greater. Exposure to lower concentrations permitted survival and development into normal larvae. The period of embryogenesis during which exposure to hydrazine was teratogenic was during neurulation. Exposure to these compounds at later or earlier periods affected viability but was not teratogenic. The malformations affected the head, trunk, and tail. The most common abnormality observed was tail kinks. Other abnormalities were microcephaly, cyclopia, shortening of the trunk, and edema. All malformed embryos also had abnormal notochords. The possible relation of notochordal abnormality to the pathogenesis of other malformations is discus
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