Use of Taxol (Paclitaxel) in Breast Cancer
作者:
Gabriel N. Hortobagyi,
Frankie A. Holmes,
Richard L. Theriault,
Aman U. Buzdar,
期刊:
Oncology
(Karger Available online 1994)
卷期:
Volume 51,
issue 1
页码: 29-32
ISSN:0030-2414
年代: 1994
DOI:10.1159/000227413
出版商: S. Karger AG
关键词: Breast cancer;Chemotherapy;Taxol;Paclitaxel;Doxorubicin
数据来源: Karger
摘要:
Taxol (paclitaxel) has demonstrated good antitumor activity against metastatic breast cancer (MBC) in phase II trials. The drug is usually well tolerated. However, severe myelosuppression, including rapidly reversible neutropenia, may necessitate dose reductions and may ultimately limit its use as a long-term treatment. Sequential or simultaneous administration of Taxol and doxorubicin may enhance response rates. There appears to be no complete cross-resistance between the two drugs. Current trials are exploring the best way to deliver this combination while keeping dose-limiting toxicity to a minimum. Additionally, single-agent trials are evaluating Taxol in extensively pretreated MBC. The results of these trials are awaited with interest.
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