Activity of Glucose-6-Phosphate Dehydrogenase among Indians Living in a Malarial Region of Mato Grosso and its Implication to the Indian-Mixed Populations in Brazil
作者:
P.H. Saldanha,
B. Lebensztajn,
S.B. Itskan,
期刊:
Human Heredity
(Karger Available online 1976)
卷期:
Volume 26,
issue 4
页码: 241-251
ISSN:0001-5652
年代: 1976
DOI:10.1159/000152810
出版商: S. Karger AG
关键词: G-6-PD;Malaria;Brazilian Indians
数据来源: Karger
摘要:
Erythrocyte glucose-6-phosphate dehydrogenase (G-6-PD) activity and electrophoresis were investigated among 154 Indians living in a region hyperendemic for malaria at Alto Xingu, Mato Grosso, Brazil. No enzyme-deficient individual was found, and all subjects belonged to enzyme type B. No statistical difference in G-6-PD levels was found between tribes and sexes. The average of G-6-PD activity of the Indians was significantly higher than the normal mean values found by the same technique in Caucasians, Negroes and Japanese of São Paulo, Brazil. The high rates of G-6-PD activity of the Indians are not correlated to an increased reticulocytosis by hypochromic anaemia and appear to be typical of Indian or Indian-mixed populations. Resistance to malaria in those populations should not involve erythrocyte G-6-PD deficiency. It is suggested that the apparent association between G-6-PD deficiency and resistance to malaria found in other populations could be a statistical accident determined by the racial correlation between the incidence of G-6-PD deficiency and sickle-cell or thalassaemic haemoglobins among Negro and Mediterranean populations
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