Immunocytochemical Detection of P-Glycoprotein: Initial Expression Correlates with Survival in Renal Cell Carcinoma Patients
作者:
Stefan Duensing,
Iris Dallmann,
Jens Grosse,
Jan Buer,
Enrique Lopez Hänninen,
Markus Deckert,
Stephan Störkel,
Hartmut Kirchner,
Hubert Poliwoda,
Jens Atzpodien,
期刊:
Oncology
(Karger Available online 1994)
卷期:
Volume 51,
issue 4
页码: 309-313
ISSN:0030-2414
年代: 1994
DOI:10.1159/000227355
出版商: S. Karger AG
关键词: Renal cell carcinoma;P-glycoprotein;Progression-free survival
数据来源: Karger
摘要:
We evaluated 28 patients with advanced renal cell carcinoma for the initial expression of P-glycoprotein (MDR1 gene product) employing immunocytochemistry. Tumor specimens were obtained upon primary tumor nephrectomy. In all patients, progression-free survival time following nephrectomy was evaluated and correlated statistically with the staining results. Progression-free survival of patients with no or very few ( < 1%) P-glycoprotein-positive tumor cells (n = 8, median survival 27.0 months) was significantly extended (p < 0.04) as compared to patients with 1% or more P-glycoprotein-positive tumor cells (n = 20, median survival 4,0 months). Correlations with histopathological tumor characteristics were insignificant. These results suggest a potential role for P-glycoprotein as a biologic parameter predictive of tumor progression in renal cell carcinoma patients.
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