Optic Neuritis and Multiple Sclerosis
作者:
E. Frick,
期刊:
European Neurology
(Karger Available online 1988)
卷期:
Volume 28,
issue 3
页码: 120-125
ISSN:0014-3022
年代: 1988
DOI:10.1159/000116246
出版商: S. Karger AG
关键词: Cell-mediated cytotoxicity;Basic protein of myelin;Encephalitogenic peptide;Cerebrosides and gangliosides;Pathogenesis of optic neuritis;Multiple sclerosis
数据来源: Karger
摘要:
On examination in the first weeks after onset of the disease, cell-mediated cytotoxicity against encephalitogenic peptide, myelin basic protein (MBP), cerebrosides and gangliosides was demonstrable in 32 (76%) of 42 patients with optic neuritis (ON). 14 patients with ON and concomitant neurological symptoms (ON/MS) had positive findings with all antigens, especially with the encephalitogenic peptide. The cytotoxic reactions against all antigens showed a close correlation with the course of ON: when the disease improved, the cytotoxicity decreased and became negative on average 4 months after ON onset. As previously reported, cell-mediated cytotoxicity against the above-mentioned antigens, especially the encephalitogenic peptide, may be considered as a pathogenetic factor in multiple sclerosis (MS). A positive reaction with this antigen in patients with ON only probably indicates the first manifestation of MS.
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