Mixed Carcinoid‐Adenocarcinoma of the Prostate With Spindle Cell CarcinoidThe Spectrum of Neuroendocrine Differentiation in Prostatic Neoplasia
作者:
A. Matthew Egan,
Tyler Youngkin,
David Bostwick,
期刊:
Pathology Case Reviews
(OVID Available online 1996)
卷期:
Volume 1,
issue 2
页码: 65-69
ISSN:1082-9784
年代: 1996
出版商: OVID
数据来源: OVID
摘要:
The authors presented and unusual mixed carcinoid-adebicarcubina of the prostate with in situ and invasive components. The carcinoid tumor showed various architectural patterns including prominent multifocal spindle cell differentiation. Spindle cell carcinoid turnor is a recognized variant in other sites, but has not, to the best of the authors knowledge, been described in the prostate. The tumor expressed markers of neuroendocrne differentiation (chromogranin, neuron-specific enolase) as well as prostate-specific antigen adn prostatie acid phosphatase. In addition, there was an in situ component with histologic and immunohistochemical features of neuroendocrine differntiation. Although neuroendocrine differentiation has been documented in prostatic intraepithelial neoplasia, there have been no reports fo in situ neuroendocrine carcinoma. This unusual tumor expands the known spectrum of neuroendocrine differentiation in prostatic neoplasia.
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