Vincristine's effect on dentinogenesis in rat incisor
作者:
TORBJØRN STENE,
期刊:
European Journal of Oral Sciences
(WILEY Available online 1979)
卷期:
Volume 87,
issue 1
页码: 39-49
ISSN:0909-8836
年代: 1979
DOI:10.1111/j.1600-0722.1979.tb01938.x
出版商: Blackwell Publishing Ltd
关键词: dentinogenesis;incisor;rat;vincristine
数据来源: WILEY
摘要:
Abstract –Vincristine was administered to 60 rats in four groups in doses of 0,1, 0,3, 0,5 and 0.7mg/kg. Histomorphologic investigation of the dentin and odontoblasts in the maxillary incisors after 1, 2 and 3 weeks revealed a moderate to severe disturbance of dentin production in some parts of the incisors. In some of the affected areas the effect seemed to be reversible in that normal‐appearing dentin was found pulpal to the dentinal derangements after 2 and 3 weeks. The distribution and severity of the lesions were similar to those previously observed 3 days after injection of the same doses of vincrist
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