Neutropenia and ThrombocytopeniaAntibodies Directed Against Circulating Neutrophils and Bone Marrow Myeloid Progenitor Cells (CFU‐C)
作者:
JEFFREY KIRSHNER,
JACK GOLDBERG,
RICHARD DINTER,
LAWRENCE BOXER,
期刊:
The American Journal of the Medical Sciences
(OVID Available online 1986)
卷期:
Volume 291,
issue 1
页码: 51-55
ISSN:0002-9629
年代: 1986
出版商: OVID
关键词: Neutropenia;Antineutrophil antibody;Myeloid progenitor cell (CFU-C)
数据来源: OVID
摘要:
The pathophysiology of a neutropenic disorder was evaluated in a 60-year-old man using myeloid progenitor cell (CFU-C), colony stimulating activity (CSA), and antineutrophil antibody assays. An immunoglobulin, present in the patient's serum at presentation, was directed against peripheral blood neutrophils, and autologous and allogeneic bone marrow CFU-C. A course of prednisone resulted in resolution of the neutropenia and a disappearance of the cytotoxic antibody. This study suggests that the patient's neutropenic disorder resulted from antibody-mediated destruction of circulating neutrophils and a suboptimal bone marrow granulopoietic response.
点击下载:
PDF
(439KB)
返 回