The protective effect of zinc sulphate in experimental sporidesmin poisoning of sheep
作者:
B.L. Smith,
P.P. Embling,
N.R. Towers,
D.E. Wright,
E. Payne,
期刊:
New Zealand Veterinary Journal
(Taylor Available online 1977)
卷期:
Volume 25,
issue 5
页码: 124-127
ISSN:0048-0169
年代: 1977
DOI:10.1080/00480169.1977.34379
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
Aqueous solutions of zinc sulphate were administered orally to sheep over 5 days (0.125, 0.5 and 2.0 g Zn++/sheep/day) to bracket a 3-day period during which sporidesmin also was dosed. The zinc sulphate treatment gave protection from the effects of sporidesmin when compared with control groups dosed sporidesmin alone. Body weight changes were improved and liverdamage scores, numbers of animals showing photosensitisation, serum levels of glutamic oxaloacetic acid transaminase and total bilirubin were lower. The protective effects of zinc sulphate were obtained at levels well abovethose required for growth and maintenance. Protection increased but at a diminishing rate with increasing dose rate of zinc. Because of the small safety margin which exists between the dose rate of zinc sulphate which will provide adequate protection and that which will cause toxicity the use of zinc for the control of facial eczema is not recommended.
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