Plasma DNA in Patients Undergoing Hemodialysis or Hemofiltration: Cytolysis in Artificial Kidney Is Responsible for the Release of DNA in Circulation
作者:
Gilbert J. Fournié,
Jacqueline Lulé,
Jean-Marc Dueymes,
Françoise Laval,
Irène Delobbe,
Isabelle Vernier,
Jacques P. Pourrat,
期刊:
American Journal of Nephrology
(Karger Available online 1989)
卷期:
Volume 9,
issue 5
页码: 384-391
ISSN:0250-8095
年代: 1989
DOI:10.1159/000168000
出版商: S. Karger AG
关键词: Plasma DNA;Artificial kidney;Cell death;Australia antigen carrier;Hemodialysis;Hemofiltration
数据来源: Karger
摘要:
Levels of circulating DNA increase under treatment by an artificial kidney. Using a new assay, levels of plasma DNA are studied in 45 patients during 99 sessions of hemodialysis or hemofiltration. Before the session, plasma DNA levels are increased in 41/99 samples and, among them, in 18/24 samples collected from hepatitis B surface antigen carriers. During the first 3 h of the session, plasma DNA levels increase whatever the method of treatment. At the 30th and 60th minute of hemodialysis, a positive gradient of plasma DNA exists between the output and the input of the artificial kidney. It is concluded that: (1) the increase in plasma DNA is related to the overall procedure of artificial kidney therapy; (2) death of leukocytes in the artificial kidney is responsible for the release and the increase in circulation of extracellular DNA.
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