Systemic absorption of salbutamol following nebulizer delivery in acute asthma
作者:
AC Penna,
KP Dawson,
P Manglick,
J Tam,
期刊:
Acta Pædiatrica
(WILEY Available online 1993)
卷期:
Volume 82,
issue 12
页码: 963-966
ISSN:0803-5253
年代: 1993
DOI:10.1111/j.1651-2227.1993.tb12609.x
出版商: Blackwell Publishing Ltd
关键词: Acute asthma;children;nebulizer;salbutamol;systemic absorption
数据来源: WILEY
摘要:
We measured plasma salbutamol concentrations in 35 children with acute asthma attacks before and after nebulizer therapy. The main finding was that older children had higher concentrations than younger children, despite similar dosage regimens. There was no influence of severity of the asthma attack on the following measures: pre‐ and post‐nebulizer concentrations, absolute and percentage change in salbutamol levels with therapy. We conclude that the theoretical risks of high concentrations in young children were not found and we suggest that the very young may indeed require higher doses due to possible problems in nebulizer technique or differences in kinet
点击下载:
PDF
(389KB)
返 回