Ependymoblastoma: a histological, immunohistological and ultrastructural study of five cases
作者:
F.F. CRUZ‐SANCHEZ,
J. HAUSTEIN,
M.L. ROSSI,
J. CERVOS‐NAVARRO,
J.T. HUGHES,
期刊:
Histopathology
(WILEY Available online 1988)
卷期:
Volume 12,
issue 1
页码: 17-27
ISSN:0309-0167
年代: 1988
DOI:10.1111/j.1365-2559.1988.tb01913.x
出版商: Blackwell Publishing Ltd
关键词: Keywords: ependymoblastoma;ependymoma;primitive neuroectodermal tumour
数据来源: WILEY
摘要:
Five ependymoblastomas were studied by means of routine histological techniques, immunohistology and electron microscopy. The tumours were characterized histologically by medium sized, poorly differentiated cells with round or oval nuclei frequently in mitosis and by ependymoblastic rosettes. Reactions for cytokeratin and neurofilament were negative and tubular material positive for glial fibrillary acidic protein was scanty. All five tumours demonstrated positivity for vimentin and S‐100 protein. Electron microscopy showed poorly differentiated cells with high nucleo‐cytoplasmic ratio and scanty cytoplasmic organelles. Sparse rosettes were present and the cells were united by junctional complexes. Frequent rudimentary or incomplete cilia, a few basal bodies and a few short intercellular glial‐like filaments were seen. Features differentiating ependymomas and anaplastic ependymomas from ependymoblastomas are discussed and the need for a definite category separating ependymoblastomas from the former tumours is empha
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