Peroxidative Events in Stored Platelet Concentrates1
作者:
E. Fagiolo,
S. Lippa,
N. Mores,
A. Oradei,
V. Aureli,
期刊:
Vox Sanguinis
(WILEY Available online 1989)
卷期:
Volume 56,
issue 1
页码: 32-36
ISSN:0042-9007
年代: 1989
DOI:10.1111/j.1423-0410.1989.tb03043.x
出版商: Blackwell Publishing Ltd
数据来源: WILEY
摘要:
Abstract.Changes in metabolic and functional activity of platelets stored as platelet concentrates in plastic bags highly permeable to gases were investigated. The following parameters were measured daily: pH, pO2, pCO2, HCO3, glucose, lactic acid, lactic dehydrogenase, cellular ATP and platelet aggregation induced by different agents (collagen and ADP). As indexes of lipid peroxidative damage, the cellular levels of conjugated dienes, malonyldialdehyde and some antioxidant molecules such as coenzyme Q10 and vitamin E were determined. A marked increase in pO2, conjugated dienes, malonyldialdehyde, lactic acid and lactic dehydrogenase activity was observed during the preservation. Platelet ATP content was unmodified and a remarkable decrease in platelet aggregability was found. pCO2, cyclooxygenase activity, vitamin E, coenzyme Q10, bicarbonate and glucose showed a rapid fall. Our data seem to indicate a preservation of platelet metabolic activity and a correlation between increased lipid peroxidation and functional impairement.
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