Contingent Negative Variation and Reaction Time in Patients with Presenile Idiopathic Cognitive Decline and Presenile Alzheimer-Type Dementia
作者:
R. Zappoli,
G. Arnetoli,
M. Paganini,
A. Versari,
A. Battaglia,
A. Grignani,
G. Sacchetti,
期刊:
Neuropsychobiology
(Karger Available online 1987)
卷期:
Volume 18,
issue 3
页码: 149-154
ISSN:0302-282X
年代: 1987
DOI:10.1159/000118409
出版商: S. Karger AG
关键词: Contingent negative variation;Reaction time;Event-related potentials;Nicergoline;Presenile idiopathic cognitive decline;Alzheimer-type dementia
数据来源: Karger
摘要:
Up to date 6 patients with initial presenile idiopathic cognitive decline (PICD) and 5 suffering from a presenile Alzheimer-type dementia (PAD) with a mean age of 59.5 were admitted to the trial. The 6 PICD patients were assigned to a double-blind nicergoline/placebo 6-month course with an oral dose of 30 mg twice a day. PAD patients were treated in an open design (nicergoline oral dose 30 mg twice a day) for at least 6 months. Until now only 4 PICD and 3 PAD patients have been treated regularly for 6 months. Two of 4 PICD patients showed a progressive enhancement of contingent negative variation (CNV), shorter reaction time (RT) and an improvement of clinical status. The other 2 PICD patients, on the contrary, showed a progressive mild worsening of CNV-RT and clinical patterns. The double-blind trial is not yet completed. CNV activity, RTs and clinical patterns progressively improved also in 2 PAD patients while in the 3rd they remained nearly unchanged or minimally worse during the 6-month treatment. The positive nicergoline effect on CNV-RT and clinical status noted in our patients appeared similar to that observed by other authors with DHEMT in patients with senile dementia of Alzheimer type. No adverse drug-related reactions were seen.
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