Problems related to the synthesis of 3‐aziridinyl‐6‐chloropyridazine
作者:
Wayne H. Nyberg,
C. C. Cheng,
期刊:
Journal of Heterocyclic Chemistry
(WILEY Available online 1964)
卷期:
Volume 1,
issue 1
页码: 1-5
ISSN:0022-152X
年代: 1964
DOI:10.1002/jhet.5570010101
出版商: Wiley‐Blackwell
数据来源: WILEY
摘要:
AbstractThe correct structure of the reported 3‐aziridinyl‐6‐chloropyridazine was found to be 3‐[β‐(1‐aziridinyl)ethylamino]‐6‐chloropyridazine, which was confirmed by n. m. r. studies. The relative ease of nucleophilic displacement of a methylsulfonyl group versus a chloro group in equivalent positions on a pyridazine or a pyrimidine ring was compared. It was observed that the chloro rather than the methylsulfonyl group was preferentially replaced, as illustrated by substitution studies of 3‐chloro‐6‐methylsulfonylpyridazine and 4‐chloro‐
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