Ceftriaxone as Short-Term Antimicrobial Chemoprophylaxis in Orthopedic Surgery: a 1-Year Multicenter Follow-Up
作者:
P. Periti,
E. Jacchia,
期刊:
European Surgical Research
(Karger Available online 1989)
卷期:
Volume 21,
issue 1
页码: 25-32
ISSN:0014-312X
年代: 1989
DOI:10.1159/000129056
出版商: S. Karger AG
关键词: Infection prophylaxis;Orthopedic surgery;Ceftriaxone;Cefamandole
数据来源: Karger
摘要:
In this multicentre study, 883 evaluable patients undergoing orthopedic surgery were randomly assigned to receive antiinfective prophylaxis with either ceftriaxone (Roce-phin®) or cefamandole. 25 patients in the ceftriaxone group and 29 patients in the cefamandole group (5.6 vs 6.5%) presented with infectious complications within the first 60 days after surgery. Delayed deep wound infections developed in only 1 of 435 patients in the ceftriaxone group compared with 4 of 413 patients in the cefamandole group. Both drugs were well tolerated. The infection rate was twice as high after surgery in conventional operating theatres than after treatment in hypersterile operating theatres (3.3 vs 6.5%); this difference is not statistically significant
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