Effect of Flufenamic Acid on Uterine Contractions and Plasma Levels of 15-Keto-13,14-Dihydroprostaglandin F2αin Preterm Labor
作者:
Arie Schwartz,
Israel Brook,
Vaclav Insler,
Fortune Kohen,
Uriel Zor,
Hans R. Lindner,
期刊:
Gynecologic and Obstetric Investigation
(Karger Available online 1978)
卷期:
Volume 9,
issue 2-3
页码: 139-149
ISSN:0378-7346
年代: 1978
DOI:10.1159/000300977
出版商: S. Karger AG
关键词: Preterm labor;Prostaglandin synthetase inhibitors;Flufenamic acid;Plasma 15-keto-13;14-dihydroprostaglandin-F2α
数据来源: Karger
摘要:
Flufenamic acid (FA), an inhibitor of the synthesis and action of prostaglandins, was administered to 18 women with preterm labor during the 28th to 36th week of gestation. In 15 patients delivery was postponed, the mean admission/delivery interval being 21.5 days. 2 patients with cervical dilatation of 4 cm delivered within 48 h despite medication. The peripheral plasma levels of 15-keto-13,14-dihydroprostaglandin F2α (KH2 PG2α) was high on admission (216 ± 24 pg/ml, mean ± SEM), declined by 50% within 2 h of instituting treatment and remained near the normal level seen in 13 controlled women after the 24th hour.
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