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Construction and synthesis of lactoferricin derivatives with enhanced antibacterial activity

 

作者: Øystein Rekdal,   Jill Andersen,   Lars H. Vorland,   John S. Svendsen,  

 

期刊: Journal of Peptide Science  （WILEY Available online 1999）
卷期: Volume 5, issue 1  

页码: 32-45

 

ISSN:1075-2617

 

年代: 1999

 

DOI:10.1002/(SICI)1099-1387(199901)5:1<32::AID-PSC172>3.0.CO;2-9

 

出版商: John Wiley&Sons, Ltd.

 

关键词: lactoferricin;antibacterial;sequence modification;QSAR;ACM, acetamidomethyl;LFB, bovine lactoferricin;LFH, human lactoferricin;LFC, caprine lactoferricin;LFM, murine lactoferricin;QSAR, quantitative structure activity relationship;PLS, projection to laten

 

数据来源: WILEY

 

摘要:

AbstractA series of peptides derived from sequences from human, bovine, murine and caprine lactoferrin has been prepared and investigated for antibacterial effect. Among the four species investigated peptides based on the bovine sequence displayed significant activity. The bovine sequence, bovine lactoferricin, showed a MIC value of 30 μg/mL onE. coliandS. aureus, whereas the three other lactoferricins possessed MIC values above 200 μg/mL. Based on these findings, novel peptides with enhanced antibacterial activities, were prepared with sequences designed by molecular modelling and structure‐activity studies. Copyright © 1999 European Peptide Society and John Wiley&Sons,

 

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