Comparative Studies on the Evaluation of the Effect of New Anthelminthics on Various Intestinal Helminthiasis in Iran
作者:
I. Farahmandian,
F. Arfaa,
H. Jalali,
M. Reza,
期刊:
Chemotherapy
(Karger Available online 1977)
卷期:
Volume 23,
issue 2
页码: 98-105
ISSN:0009-3157
年代: 1977
DOI:10.1159/000221977
出版商: S. Karger AG
关键词: Chemotherapy of helminthiasis;Ascaris;Ancylostoma;Tricho-strongylus;Pyrantel pamoate;Mebendazole;Levamisole;Thiabendazole;Be-phenium hydroxynaphthoate
数据来源: Karger
摘要:
The effect of pyrantel pamoate, levamisole, mebendazole, thiabendazole and bephenium hydroxynaphthoate on various intestinal helminths were evaluated among the inhabitants of four villages in the Dezful area southwest of Iran. A total number of 328 persons, all infected simultaneously with Ascaris and hookworm (Ancylostoma duodenale) and 49.2% with Trichostrongylus spp., were randomly divided into six groups. One group was kept as the control and the other five were each treated with one compound. Follow-up examinations showed that all of the drugs used were highly effective on Ascaris, and the differences in the cure rate were not statistically significant except for bephenium hydroxynaphthoate which showed a lower cure rate. For hookworm, cure rates of 100, 90, and 85% were observed with levamisole, pyrantel pamoate and bephenium hydroxynaphthoate, respectively. Cure rates observed with mebendazole and thiabendazole were 35 and 51%, respectively. For Trichostrongylus, the highest cure rate was achieved with levamisole, followed by thiabendazole and mebendazole. While the percentage of people showing side-effects was rather low for all drugs, thiabendazole and bephenium hydroxynaphthoate produced a higher, and levamisole a lower, percentage of side effects.
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