The Pepsinogens of Cat Gastric Mucosa and the Pepsins Derived from Them
作者:
B. Shaw,
Christine L. Wright,
期刊:
Digestion
(Karger Available online 1976)
卷期:
Volume 14,
issue 2
页码: 142-152
ISSN:0012-2823
年代: 1976
DOI:10.1159/000197919
出版商: S. Karger AG
关键词: Antrum;Cats;Chromatography gel;Electrophoresis;Fundus;Gastric mucosa;Pepsin
数据来源: Karger
摘要:
Fundic mucosal extracts of the cat were examined by chromatography using DEAE-cellulose at pH 5.3. The peaks of proteolytic activity located by this method were shown to be heterogeneous on electrophoresis. By electrophoresis of individual homogenous chromatographic fractions 9 separate zones of proteolytic activity were detected. One zone did not migrate from the origin and is possibly a non-pepsinogen gastric protease. Simultaneous electrophoresis of pepsinogens and pepsins indicated that each pepsinogen gave rise to one pepsin. One zymogen gives rise to a pepsin active with the synthetic substrate acetyl-L-phenylalanyl-L-diiodotyrosine (APDT).
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