首页   按字顺浏览 期刊浏览 卷期浏览 Menopause in female rhesus monkeys
Menopause in female rhesus monkeys

 

作者: Margaret L. Walker,  

 

期刊: American Journal of Primatology  (WILEY Available online 1995)
卷期: Volume 35, issue 1  

页码: 59-71

 

ISSN:0275-2565

 

年代: 1995

 

DOI:10.1002/ajp.1350350106

 

出版商: Wiley Subscription Services, Inc., A Wiley Company

 

关键词: Rhesus monkey;Macaca mulatta;Menopause estradiol;luteinizing hormone;aging

 

数据来源: WILEY

 

摘要:

AbstractFifteen female rhesus monkeys (Macaca mulatto), ranging in age from 8 to 34 years, were studied for one year to characterize the endocrine and menstrual changes associated with menopause in this species. Five monkeys were premenopausal; these younger monkeys, ages 8–11 years, menstruated and showed cyclic ovarian activity during the 12–month study period, as evidenced by menses and periodic elevations of serum estradiol (E2) and luteinizing hormone (LH) concentrations. Four females, ages 24–26 years, were in transition to menopause. Two of these perimenopausal females menstruated and secreted E2and LH in a periodic fashion; the other two females showed elevated LH concentrations, consistently low E2levels, and no evidence of menstruation. Six females, ages 27–34 years, were clearly postmenopausal; LH concentrations were high, whereas E2concentrations were uniformly low. There was a significant inverse correlation between basal E2concentrations and age, and a significant positive correlation between age and LH concentrations across all 15 animals. Hormonal changes indicative of ovulation, when they occurred, were generally restricted to the winter and early spring months. Histological analysis of ovaries from four postmenopausal females revealed little or no evidence of active folliculogenesis. These data indicate that menopause in female rhesus monkeys does not occur until the second half of thethird decade of life. © 1995 Wiley

 

点击下载:  PDF (813KB)



返 回