Effect of Jejunal Resection on the Gastric Acid Secretory Response to Pentagastrin, Histamine and Feeding in Dogs
作者:
C. Brihaye,
M.C. Woussen-Colle,
J.M. Limbosch,
J. de Graef,
期刊:
Digestion
(Karger Available online 1976)
卷期:
Volume 14,
issue 2
页码: 153-162
ISSN:0012-2823
年代: 1976
DOI:10.1159/000197920
出版商: S. Karger AG
关键词: Dogs;Gastric acidity determination;Gastric juice;Gastrin;Gastrointestinal hormones;Histamine
数据来源: Karger
摘要:
In dogs with gastric fistulas and denervated pouches from the oxyntic area, the acid secretory responses to a meal and to graded doses of histamine and pentagastrin were measured before and after resection of the upper half of the small bowel. Intestinal resection caused a small but significant increase in submaximal and maximal responses from the pouch to histamine and pentagastrin without modification of the ED50. This effect was not observed in the innervated stomach. The response from the pouch to feeding was markedly increased and prolonged. These data indicate that both an increase in stimulation and an increase of the response to this stimulation are responsible for the increased acid secretion observed in the pouch when resected dogs were fed. These effects could be explained by the withdrawal of inhibitors of intestinal origin.
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