Homeobox genes and development of the vertebrate CNS
作者:
David G. Wilkinson,
期刊:
BioEssays
(WILEY Available online 1989)
卷期:
Volume 10,
issue 2‐3
页码: 82-85
ISSN:0265-9247
年代: 1989
DOI:10.1002/bies.950100211
出版商: Wiley Subscription Services, Inc., A Wiley Company
数据来源: WILEY
摘要:
AbstractThe discovery of homeobox genes in vertebrates may allow analysis of a basic problem in developmental neurobiology: how regional differences in CNS organization are specified during development. This view is based on the roles defined for homologous genes inDrosophiladevelopment, and is supported by studies of the patterns of homeobox gene expression in vertebrate embryos. Homeobox genes comprise a multigene family, members of which are expressed in different spatially restricted domains along the anterior‐posterior axis of the CNS. These observations are consistent with homeobox genes having roles in the positional specification of CNS organization, and experimental tests of this should be forthcoming shortl
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