Studies of an outbreak of acute hepatitis A: I. Complement level fluctuation
作者:
G. M. Baer,
J. A. Walker,
P. A. Yager,
期刊:
Journal of Medical Virology
(WILEY Available online 1977)
卷期:
Volume 1,
issue 1
页码: 1-7
ISSN:0146-6615
年代: 1977
DOI:10.1002/jmv.1890010102
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: hepatitis;complement;immune complexes
数据来源: WILEY
摘要:
AbstractAn outbreak of hepatitis A occurred in a rural elementary school in Colbert County, Alabama, in October and November 1972. The outbreak was caused by sewage‐contaminated drinking water and involved 49 children and 1 adult. Acute and convalescent serum samples were obtained from the hepatitis patients, and from each of 24 unafflicted matched controls at the same time. Strikingly, the levels of the third and fourth components of complement (C'3 and C'4) were markedly reduced in the acute samples from the sick children but returned to normal in the convalescent ones; the C'3 and C'4 levels in the healthy matched controls were not reduced. In addition, antigen‐antibody complexes were found in convalescent sera from some of the sick children. These findings indicate that immune complexes are present in acute hepatitis A and suggest that the techniques for future virus isolation may have to be alte
点击下载:
PDF
(373KB)
返 回