Pharmacokinetics of Murine Tumor Necrosis Factor
作者:
FlickDavid A.,
GlffordGeorge E.,
期刊:
Immunopharmacology and Immunotoxicology
(Taylor Available online 1986)
卷期:
Volume 8,
issue 1
页码: 89-97
ISSN:0892-3973
年代: 1986
DOI:10.3109/08923978609031087
出版商: Taylor&Francis
数据来源: Taylor
摘要:
AbstractThein vivoadministration of tumor necrosis factor (TNF) provides a new approach to the immunotherapeutic treatment of tumors. We evaluated the pharmacokinetics of murine tumor necrosis factor in mice as a model for application in the human system. TNF had a clearance of 0.013 ml/min/g and a serum half life of 10.5 minutes. Its volume of distribution was consistant with the extracellular space. This information can provide parameters by which to select optimal modes of treatment for eradication ofin vivoneoplasms.
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