Comparative Effects of Intravenously Administered Alizapride and Prochlorperazine in Cisplatin-Induced Emesis
作者:
RocheH.,
HymanG.,
NahasG.,
StooplerM.,
EllisonR.,
DesjardinsR.,
期刊:
Cancer Investigation
(Taylor Available online 1987)
卷期:
Volume 5,
issue 2
页码: 89-93
ISSN:0735-7907
年代: 1987
DOI:10.3109/07357908709018461
出版商: Taylor&Francis
数据来源: Taylor
摘要:
AbstractA randomized, double blind crossover trial compared the antiemetic effects of alizapride, a benzamide, and prochlorperazine, a phenothiazine, both administered intravenously to 32 patients treated with chemotherapy combinations containing cisplatin. The total dose of alizapride administered to each patient was 14 mg/kg, and of prochlorperazine. 56 mg/kg, divided in five doses. Although alizapride resulted in complete protection against emesis in 31% of the patients during their first course of cisplatin therapy, 42% of those who received alizapride had five or more episodes of emesis. Although prochlorperazine was less effective in offering complete protection against emesis, only 15% of the patients receiving this drug vomited more than five times. The duration of emesis during prochlorperazine treatment was also significantly shorter than during alizapride therapy (p>0.02). Optimal dosage and pharmacokinetic distribution of both drugs should be investigated further.
点击下载:
PDF (325KB)
返 回