Effect of intra‐articular injections of methylprednisolone on body weight in rats. A circadian rhythm
作者:
K. Ogata,
D. J. Simmons,
期刊:
Journal of Interdisciplinary Cycle Research
(Taylor Available online 1976)
卷期:
Volume 7,
issue 3
页码: 223-227
ISSN:0022-1945
年代: 1976
DOI:10.1080/09291017609359524
出版商: Taylor & Francis Group
关键词: Blood corticosteroid rhythm;chronopharmacology;circadian rhythm;methylprednisolone acetate
数据来源: Taylor
摘要:
Clock hour independent groups of young female rats received a series of 3 alternate day intra‐articular injections of methylprednisolone acetate. All rats lost body weight, but the change was minimal when the injections were given in the late afternoon (‐30.8 g) vs the night (‐42.4 g, P < .02). The data imply that methylprednisolone acetate, which is designed to be locally active in joint spaces, can be absorbed into the circulation and that the rate of absorption is subject to circadian control.
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