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An Opioid Agonist with Preference for κ‐Opioid Receptors: (−)‐N‐Cyclopropylmethylmorphinan‐6‐one

 

作者: Helmut Schmidhammer,   Ellen Trenker,   Willy P. Burkard,   Lislott Eggstein‐Aeppli,   Fridolin Hefti,   Mark I. Holck,  

 

期刊: Archiv der Pharmazie  （WILEY Available online 1990）
卷期: Volume 323, issue 1  

页码: 27-29

 

ISSN:0365-6233

 

年代: 1990

 

DOI:10.1002/ardp.19903230108

 

出版商: WILEY‐VCH Verlag

 

数据来源: WILEY

 

摘要:

AbstractN‐Cyclopropylmethyl‐ and N‐cyclobutylmethylmorphinan‐6‐one (3and4, respectively) were prepared from N‐methylmorphinan‐6‐one (1). The pharmacological studies showed3and4to be potent opioid agonists. Compound3was found to have preference for κ rather than μ

 

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