AbstractWhile releases of hazardous/toxic fluids from pressurized pipelines are infrequent, the potential for a catastrophic event resulting from such a release warrants extraordinary care of the hazardous/toxic piping systems containing these fluids, during the entire plant life cycle.System identification, segregation, material and component selection, construction techniques, and preventative maintenance programs all contribute to improved system reliability, and are discussed herein. Methods to mitigate damages in the event of a failure are also discussed.