A patient with bullous pemphigoid, not responding to prednisone, had impaired cellular immunity. Transfer factor (TF) was given in doses of 10 U/m2 intramuscularly to improve T cell immunity, at a frequency of 3 times to once a week. Clinical improvement fluctuated with changes in the frequency of TF injections. The skin has been clear of the lesions for the past 9 months. Her T cell functions became normal and serum IgE decreased from 900 U/ml to 270 U/ml. She has received a total of 1,732 U of TF. This report is intended to encourage investigation into T cell functions in patients with bullous pemphigoid and controlled trials of TF in this disease.