Isocratic HPLC Separation of Several Racemic Drugs with Two Stereogenic Centers on a Pirkle Urea-Type Chiral Stationary Phase
作者:
HassanY. Aboul-Enein,
IbrahimA. Al-Duraibi,
期刊:
Journal of Liquid Chromatography & Related Technologies
(Taylor Available online 1998)
卷期:
Volume 21,
issue 12
页码: 1817-1831
ISSN:1082-6076
年代: 1998
DOI:10.1080/10826079808005894
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
A simple and rapid isocratic enantiomeric separation of several racemic drugs with two stereogenic centers, namely for-moterol, labetalol, nadolol, indenolol, and U-54494A, was achieved under normal phase mode using a urea-type chiral stationary phase (CSP) column of (S)-indoline-2-carboxylic acid and (R)-1-(α-naphthyl) ethylamine, known as Chirex 3022 column. Labetalol and formoterol were resolved successfully into its four enantiomers. Furthermore, racemate mixture of U-54494A has been resolved into its individual enantiomers. However, nadolol and indenolol was partially separated.
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