Enzymatic and ultrastructural study of lysosomes in rats bearing radiation‐induced thyroid follicular carcinoma
作者:
James R. Starling,
Kelly H. Clifton,
Diane H. Norback,
期刊:
Journal of Surgical Oncology
(WILEY Available online 1981)
卷期:
Volume 16,
issue 1
页码: 15-25
ISSN:0022-4790
年代: 1981
DOI:10.1002/jso.2930160104
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: lysosomal enzymes;lysosomes;thyroid cancer
数据来源: WILEY
摘要:
AbstractRadiation‐induced well‐differentiated and poorly differentiated follicular thyroid cancers were transplanted into the intrascapular fat pads of male Fisher 144 rats. The tumors grew in the recipient rats and after a time interval were removed and studied along with normal rat thyroids for lysosomal activity and ultrastructural characteristics. Plasma from experimental and control rats was also studied for lysosomal activity. Rats with radiation‐induced thyroid carcinoma had a decrease in growth rate compared with normal rats. There was no significant increase in plasma lysosomal enzymes in the experimental rats. Well‐differentiated thyroid carcinomatous tissue showed increased total activities of lysosomal enzymes as well as a difference in subcellular distribution compared with normal and poorly differentiated carcinomatous tissue. Electron microscopy of normal and carcinomatous tissue demonstrated the greatest number of lysosomes in the well‐differentiated carcinoma and the fewest in the poorly differentiated
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