The influence of different levels of dietary fat on the incidence and growth of mnu‐induced mammary carcinoma in rats
作者:
AksoyMeral,
BergerMartinR.,
SchmählDietrich,
期刊:
Nutrition and Cancer
(Taylor Available online 1987)
卷期:
Volume 9,
issue 4
页码: 227-235
ISSN:0163-5581
年代: 1987
DOI:10.1080/01635588709513931
出版商: Taylor&Francis Group
数据来源: Taylor
摘要:
AbstractThis study describes the influence of isocalorically fed diets (containing different amounts of fat) on tumor incidence and parameters of fat metabolism in female Sprague‐Dawley rats. Comparisons are made between rats induced with methylnitrosourea (25 mg/kg body wt) and untreated controls (Group I). The animals received either control diets (3.9% fat by weight, Groups I and II) or fat‐enriched diets (10.7%, GroupIII; 15.6%, Group IV; 21.4%, Group V) over a period of 180 days. At the termination of the experiment, intake of the diet containing 10.7% fat by weight (24% fat per total calories) was associated with the highest tumor incidence. Comparing the different diets, liver lipid concentrations in the individual groups increased with increasing dietary fat, whereas the total lipid in plasma decreased. During the feed‐ingperiod, total lipid of the liver and plasma, and plasma cholesterol, increased in all groups, but triglycerides of plasma decreased. However, when plasma cholesterol and triglycerides were calculated as a relative amount of total lipid in plasma, cholesterol was found to be significantly decreased in Groups III and IV, and triglycerides were increased in Group III but decreased significantly in Groups I, II, and Vat the end of the experiment.
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