Effects of Long-Term L-Dopa Therapy on Carbohydrate Metabolism in Patients with Parkinson’s Disease
作者:
G. Rosati,
M. Maioli,
I. Aiello,
A. Farris,
V. Agnetti,
期刊:
European Neurology
(Karger Available online 1976)
卷期:
Volume 14,
issue 3
页码: 229-239
ISSN:0014-3022
年代: 1976
DOI:10.1159/000114744
出版商: S. Karger AG
关键词: Carbohydrate metabolism;L-Dopa;Parkinson’s disease;Insuline release
数据来源: Karger
摘要:
Carbohydrate metabolism and insulin secretion were investigated in 26 patients with Parkinson’s disease before and during L-dopa treatment. Oral glucose tolerance tests were performed on 13 patients treated with L-dopa alone and on 7 patients treated with L-dopa combined with Carbidopa. Intravenous glucose tolerance tests were performed on additional 6 patients treated with L-dopa alone. Results indicate that chronic L-dopa administration does not modify glucose metabolism. It was observed only a significant decrease of insulin secretion after oral glucose in the early phase (15th day) of treatment with L-dopa alone. This temporary effect may be related to the peripheral conversion of L-dopa to dopamine since insulin secretion during combined therapy was normal. The mechanism by which L-dopa transiently inhibits insulin release is not clear. Perhaps the oral administration of L-dopa alone causes an alteration in some gastrointestinal functions which are involved in the handling of oral glucos
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