INTERACTIVE EFFECT OF GENES ASSOCIATED WITH IMMUNOGLOBULIN ALLOTYPES AND HLA SPECIFICITIES ON SUSCEPTIBILITY TO HAEMOPHILUS INFLUENZAE DISEASE
作者:
Dan M. Granoff,
Eyla Boies,
Janet Squires,
Janardan P. Pandey,
Brian Suarez,
John Oldfather,
Glenn E. Rodey,
期刊:
International Journal of Immunogenetics
(WILEY Available online 1984)
卷期:
Volume 11,
issue 3‐4
页码: 181-188
ISSN:1744-3121
年代: 1984
DOI:10.1111/j.1744-313X.1984.tb01055.x
出版商: Blackwell Publishing Ltd
数据来源: WILEY
摘要:
SUMMARYGenes associated with immunoglobulin (Ig) allotype determinants are important in regulation of immune responses to bacterial polysaccharides. Furthermore, loci associated with Ig allotypes have been reported to interact with those associated with the major histocompatibility complex and affect susceptibility to certain diseases. In the present study we determined the frequencies of certain Gm phenotypes in patients withHaemophilusmeningitis or epiglottitis and in controls. HLA‐A, ‐B and ‐DR specificities had previously been determined in the majority of these subjects. Although no Ig phenotype was associated with increased or decreased relative risk of disease, the frequencies of several combinations of HLA specificities and Ig phenotypes were significantly different from those of controls. Thus, for subjects with the Gm phenotype (1, 3, 17; 23; 5, 13, 21), the risk ofHaemophilusmeningitis or epiglottitis was lower in individuals with HLA‐B5 than in those without this specificity (odds ratio<0.1, P<0.004). In contrast, for subjects with the closely related Gm phenotype differing only by the absence of Gm(23), (1, 3, 17; 5, 13, 21), the risk of disease was higher in those with HLA‐DR3 than in individuals who lacked DR3 (odds ratio = 11.0, P = 0.02). Although the present data require confirmation in an independent sample, they suggest that complex interactions between genes at two independent loci controlling HLA and Ig allotypes, respectively, may affect susceptibility toHaemophi
点击下载:
PDF
(473KB)
返 回