Efficacy of Placebo in the Treatment of Patients with Amenorrhea
作者:
P.G. Crosignani,
A.M. Mattei,
P. Maggioni,
G. Testa,
E. Negri,
期刊:
Gynecologic and Obstetric Investigation
(Karger Available online 1994)
卷期:
Volume 37,
issue 3
页码: 183-184
ISSN:0378-7346
年代: 1994
DOI:10.1159/000292555
出版商: S. Karger AG
关键词: Amenorrhea;Placebo;Hypothalamus
数据来源: Karger
摘要:
Thirty-two amenorrheic patients were treated with a tablet oral placebo preparation for a period varying from 30 to 180 days. Another 24 amenorrheic patients were also treated with a placebo administered i.m. for a period varying from 30 to 120 days. As a consequence of the treatment, 27 patients (48%) had menstrual bleedings. The progestogen withdrawal test responsive patients were more responsive to placebo (73 vs. 14% in the progestogen withdrawal test nonresponsive, p < 0.001). The time lag between starting the medication and the first bleeding varied between 4 and 120 days with a mean value of 3 3.9 (SD 26.3). Oral placebo was more effective than the intramuscular form (56 vs. 38%, p < 0.05).
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