Influence of Some Antineoplastic Agents on Genetic Exchange inBacillus subtilis
作者:
Maria Teresa Pérez Ureña,
Paloma López,
Manolo Espinosa,
Antonio Portoles,
期刊:
Chemotherapy
(Karger Available online 1980)
卷期:
Volume 26,
issue 5
页码: 309-315
ISSN:0009-3157
年代: 1980
DOI:10.1159/000237922
出版商: S. Karger AG
关键词: Competence development;Antineoplastics;Transformation;DNA binding
数据来源: Karger
摘要:
The influence of three categories of anti-cancer agents on competence development and on the binding of homologous DNA to cells have been studied in the Bacillus subtilis transformation system. Treatment of cells developing competence with testolactone resulted in a slight enhancement of transformation at high doses (50 and 100 μg/ml) of the drug, but this process was inhibited at 25 μg/ml. DNA binding was unaffected by this drug. DNA-interacting agents (daunomycin, prospidine, peptichemio and mithramycin) usually inhibited DNA-mediated transformation in a higher extent than DNA binding. Antimetabolites of DNA synthesis were also tested: dacarbazine did not greatly inhibit the binding and expression of donor DNA. 5-Fluorouracil appeared to slightly enhance transformation at low levels (1 μg/ml), although it was inhibited at higher dos
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