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A bayesian approach to bioassay. technical report m498

 

作者: Richard M. Fagerstrom,   Duane A. Meeter,  

 

期刊: Communications in Statistics - Simulation and Computation  (Taylor Available online 1983)
卷期: Volume 12, issue 5  

页码: 541-558

 

ISSN:0361-0918

 

年代: 1983

 

DOI:10.1080/03610918308812341

 

出版商: Marcel Dekker, Inc.

 

关键词: bioassay;multiple regrssion;average level estimator;interpolated estimator;Bayesian inference;fractional factorial;variance reduction techniques;efficiency

 

数据来源: Taylor

 

摘要:

We describe the design and analysis for a simulation experiment to compare the mean-squared errors (MSE's) of two quantile estimators defined for random walk designs. The dependence of the easily computed MSE of the first estimator on the levels of five factors is examined via multiple regression. This information is used to plan a simulation to compute the MSE of the second estimator using a fraction of a 3352factorial allowing uncorrelated estimates for all main effects and the two-factor interactions of a specified factor. Efficient estimation of the MSE of the second estimator is attempted through antithetic and control variate techniques of variance reduction, with modest success.

 

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