Plasma fucosyltransferase as an indicator of imminent blastic crisis
作者:
Ila Shah‐Reddy,
David H. Kessel,
Ta‐Hsu Chou,
Ila Mirchandani,
Urmilla Khilanani,
期刊:
American Journal of Hematology
(WILEY Available online 1982)
卷期:
Volume 12,
issue 1
页码: 29-37
ISSN:0361-8609
年代: 1982
DOI:10.1002/ajh.2830120105
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: fucosyltransferase;chronic granulocytic leukemia;blast crisis
数据来源: WILEY
摘要:
AbstractPlasma fucosyltransferase activity was evaluated as an indicator of an impending blastic transformation in 25 patients with chronic granulocytic leukemia (CGL). Fifteen age‐and sex‐matched controls were also studied. The level of enzyme activity was significantly higher in the plasma of patients with blastic transformation (1,630 ± 570 units) compared with steady state chronic granulocytic leukemia (509 ± 110 units) and normal controls (354 ± 57 units). In three patients with CGL, a rise in fucosyltransferase activity preceded any other clinical or laboratory parameter of blastic transformation by 16–
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