SummaryA method was developed for determining 3 sulphonamide drug residues in honey at the level of 1 ppm. Residues were extracted with acetone, evaporated to dryness, redissolved in twice-distilled water containing sodium hydroxide, and then directly analysed by reverse-phase high-pressure liquid chromatography. The chromatographic conditions of the analyses and the degradation rates of sulphonamide residues in honey are described and discussed.