Incorporation, after Single and Repeated Application of Radioactive Labelled DH-Ergot Alkaloids in Different Organs of the Cat, with Special Reference to the Brain
作者:
P. Iwangoff,
A. Enz,
W. Meier-Ruge,
期刊:
Gerontology
(Karger Available online 1978)
卷期:
Volume 24,
issue 1
页码: 126-138
ISSN:0304-324X
年代: 1978
DOI:10.1159/000212306
出版商: S. Karger AG
关键词: Distribution studies;DH-ergot alkaloids;Gradient centrifugation studies;Repeated application of drugs;Drug clearance
数据来源: Karger
摘要:
1 h after intravenous administration, 3H-DH-ergot alkaloids showed maximal uptake in the range of 10-5M in various visceral organs, and of 10-7M in most parts of the CNS of the cat. The clearance function in both groups of tissues was logarithmical linear, the slope of the straight line for the parts of the CNS being considerably flatter. Repeated administration of these drugs demonstrated a higher retention in the CNS than in the other organs. The single-dose level in the CNS is reinforced and, in contrast to liver and lung, maintained for at least 24 h.
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