Antibiotherapy ofSerratia marcescensSepticemia in Children
作者:
F. Baquero,
J.G. Hortelano,
M. Navarro,
A. Scarpellini,
P. Jara,
T. Cañedo,
A. Rodríguez,
期刊:
Chemotherapy
(Karger Available online 1977)
卷期:
Volume 23,
issue 1
页码: 416-422
ISSN:0009-3157
年代: 1977
DOI:10.1159/000222084
出版商: S. Karger AG
关键词: Fosfomycin;Septicemia;S. marescens;Sensitivity and interaction;Gentamicin;Carbenicillin
数据来源: Karger
摘要:
The clinical and bacteriological response of 38 treatments performed on 24 children (11 of them neonates) carrying out separate treatments with carbenicillin (2 treatments), gentamicin [4], fosfomycin [6], and associated treatments with gentamicin plus carbenicillin [6], fosfomycin plus gentamicin [18] and fosfomycin plus carbenicillin [2] are considered. The clinical cure was obtained in 21 children (87.5%). The most effective treatment was fosfomycin plus gentamicin; both antibiotics showed synergism in vitro on isolated Serratia strains. A dosage of 75 mg/kg fosfomycin enables serum levels of about 32 μg/ml during 4–5 h, being this level higher to the MIC of all isolated strains of S. marcescens.<
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