Apolipoprotein B Immunochemical Heterogeneity in Dialysed Patients with Chronic Renal Failure and Patients with Coronary Artery Stenosis
作者:
Richard Reade,
Venance Equagoo,
Claude Cachera,
Patrick Duriez,
Michel Dracon,
Jean-Marie Bard,
Catherine Fievet,
Michel Bertrand,
Albert Tacquet,
Jean-Charles Fruchart,
期刊:
American Journal of Nephrology
(Karger Available online 1989)
卷期:
Volume 9,
issue 2
页码: 110-114
ISSN:0250-8095
年代: 1989
DOI:10.1159/000167948
出版商: S. Karger AG
关键词: Chronic renal failure;Coronary artery disease;Apolipoprotein B;Monoclonal antibodies
数据来源: Karger
摘要:
Serum cholesterol, triglyceride, apolipoprotein B (apo B) and the cholesterol and phospholipid content of apo-B-containing particles was determined in 41 male patients on dialysis for chronic renal failure, in 41 male patients with coronary artery disease selected on the basis of a total cholesterol level below 6.72 mmol/l and in 41 male control subjects of similar age. Apo B was assessed as total B protein determined using polyclonal antibodies and also by measuring the expression of epitopes recognized by three different monoclonal antibodies (BL3, BL5 and BL7). Triglyceride was increased (p < 0.01) and cholesterol was decreased (p < 0.01) in the dialysed patients with chronic renal failure. Total apo B was similar in the three tested groups while the expression of the BL7 epitope was increased in the group of dialysed patients with chronic renal failure (p < 0.001). The expression of BL3 and BL5 epitopes was increased in patients with coronary artery disease (BL3: p < 0.05; BL5: p < 0.02) but not in dialysed patients with chronic renal failure. These results suggest an abnormal composition and an immunological heterogeneity of apo-B-containing lipoprotein particles in patients with coronary artery stenosis and in dialysed patients with chronic renal failure.
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