Penetration of Oral Cefuroxime Axetil into the Human Aqueous Humor
作者:
M. Ghia,
R. Lotti,
C. Traverso,
F. Mattioli,
A. Martelli,
期刊:
Ophthalmologica
(Karger Available online 1997)
卷期:
Volume 211,
issue 4
页码: 229-231
ISSN:0030-3755
年代: 1997
DOI:10.1159/000310796
出版商: S. Karger AG
关键词: Cefuroxime axetil;Aqueous humor concentrations
数据来源: Karger
摘要:
The purpose of this study was to investigate the penetration into the aqueous humor of cefuroxime after a single oral dose as cefuroxime axetil. Fourteen patients scheduled for cataract extraction received a single oral dose of cefuroxime axetil corresponding to 500 mg of cefuroxime 2–8 h preoperatively. Aqueous humor samples were obtained at the beginning of the cataract surgery and blood samples were drawn at the time of anesthesia. Cefuroxime levels were determined by high-performance liquid chromatography. The aqueous levels were (mean ± SEM) 0.48 ± 0.13 μg/ml from 3 to 8 h after administration. Serum levels averaged 3.80 ± 0.58 μg/ml. These data indicate that detectable levels of cefuroxime, exceeding the MIC of some bacterial species that frequently cause intraocular infections, may be achieved in uninflamed eyes after a low dose of cefuroxime axetil.
点击下载:
PDF
(1432KB)
返 回