Aminonucleoside Nephrosis in Rats
作者:
Adalberto Sessa,
Ferruccio Conte,
Aniello Cioffi,
Giuseppe D’Amico,
期刊:
Nephron
(Karger Available online 1975)
卷期:
Volume 14,
issue 3-4
页码: 299-308
ISSN:1660-8151
年代: 1975
DOI:10.1159/000180460
出版商: S. Karger AG
关键词: Aminonucleoside nephrosis;Chronic glomerulonephritis;Electron microscopy;Glomerular permeability;Indomethacin;Podocytes
数据来源: Karger
摘要:
The concomitant administration of Indomethacin reduced the biochemical signs of the nephrotic syndrome induced in rats by aminonucleoside; in the rats treated with both drugs a morphological picture suggesting activated function of podocytes was found at the electron microscopic examination of the renal glomerular structures, together with the lesions characteristic of the aminonucleoside nephrosis. The possibility is discussed that Indomethacin could modify the permeability of the glomerular capillary wall by stimulating thepodocytes to synthesize basement membrane material.
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